An Overview on Gastroretentive Drug Delivery System
نویسندگان
چکیده
Oral controlled release and site specific drug delivery system has been of great interest in pharmaceutical field to achieve improved therapeutic advantage. Drug absorption in the gastrointestinal tract is a highly variable procedure and prolonging gastric retention of the dosage form extends the time for drug absorption. Gastro retentive drug delivery system is one of such novel approaches to prolong gastric residence time, thereby targeting site specific drug release in the stomach for local or systemic effects. This approach is useful particularly for the drugs which have narrow absorption window in the upper part of gastro intestinal tract. Various approaches of gastro retentive drug delivery system, such as floating and non-floating, have been discussed in this review. This review also gives an overview of merits, demerits and evaluation parameters of gastro retentive system.
منابع مشابه
Gastroretentive Drug Delivery Systems: A Review of Formulation Approaches
Gastroretentive dosage forms (GRDF) has received significant interest in the past few decades as they can improve the limitation of most conventional and oral controlled release drug delivery system related to fast gastric-emptying time. An optimum GRDF system can be defined as a system which retains in the stomach for a sufficient time interval against all the physiological barriers, releases ...
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